Effect of single dose preemptive intravenous paracetamol, dexamethasone, and magnesium sulfate on perioperative hemodynamic variables and post-operative nausea, vomiting, and pain in open cholecystectomy done under general anesthesia: A prospective, randomized, and single-blind study

Background: Pain due to open cholecystectomy can result in delayed recovery and poor operative outcomes. Multimodal approaches pain control cause functional improvement. We compared the efficacy of paracetamol 1 g, dexamethasone 8 mg, magnesium sulfate 2 g with normal saline over perioperative hemodynamics post-operative patients undergoing under general anesthesia. Aims Objectives: This study conducted assess effect preemptive intravenous paracetamol, dexamethasone, on hemodynamic variables (primary outcome) nausea, vomiting, (secondary cholecystectomy. Materials Methods: Sixty ASA Grade I/II were randomized into two groups receive either 100 ml iv (Group C, n=30) or infusion containing inj. mg (group PDM, n=30), 20 min before induction. Intraoperative data, scores, incidence nausea vomiting recorded. Results: pulse rate was significantly higher at intubation 15 after group intraoperative systolic, diastolic, mean arterial blood pressure until 60 min. Post-operative 180 PONV reduced PDM 90 Conclusion: Preemptive provided better stability hemodynamics, control.